| NCT07429006 | SAD and MAD Study of AKB-9090 in Healthy Adult Participants | Phase 1 | Recruiting | Mar 16, 2026 | 2026-12 (estimated) |
| NCT07268638 | A Study of Praliciguat in Participants With Focal Segmental Glomerulosclerosis (FSGS) | Phase 2 | Recruiting | Dec 3, 2025 | 2027-06 (estimated) |
| NCT06419205 | A Phase 2 Study to Evaluate the Safety, PD, PK, and Clinical Activity of ADX-097 in Participants With IgAN, LN or C3G | 2 | Recruiting | Jul 30, 2026 | 2028-02 (estimated) |
| NCT06901505 | To Evaluate the Efficacy of Three Times Weekly (TIW) Vadadustat Compared to Standard of Care ESA in Patients With Anemia of CKD Receiving In-Center Hemodialysis | Phase 3 | Completed | Jul 24, 2025 | Aug 12, 2026 (actual) |
| NCT05082584 | Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease Naive to Erythropoiesis-Stimulating Agents | Phase 3 | Withdrawn | 2025-01 | 2026-07 (estimated) |
| NCT05082571 | Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease | Phase 3 | Withdrawn | 2025-01 | 2026-07 (estimated) |
| NCT04313153 | Trial Evaluating the Efficacy and Safety of Oral Vadadustat Once Daily (QD) and Three Times Weekly (TIW) for the Maintenance Treatment of Anemia in Hemodialysis Subjects Converting From Erythropoiesis-Stimulating Agents (ESAs) | Phase 3 | Completed | May 27, 2020 | Nov 26, 2021 (actual) |
| NCT04707768 | Study Evaluating the Efficacy and Safety of Dose Conversion From a Long-acting Erythropoiesis-stimulating Agent (Mircera®) to Three Times Weekly Oral Vadadustat for the Maintenance Treatment of Anemia in Hemodialysis Subjects | Phase 3 | Completed | Jun 18, 2021 | Jan 6, 2023 (actual) |
| NCT03799627 | Study of Vadadustat in Hemodialysis Participants With Anemia Switching From Epoetin Alfa | Phase 2 | Completed | Jan 31, 2019 | Jun 5, 2020 (actual) |
| NCT03217591 | A Study to Evaluate the Soluble Guanylate Cyclase (sGC) Stimulator IW-1973 in Diabetic Nephropathy / Diabetic Kidney Disease as Measured by Albuminuria | Phase 2 | Completed | Aug 1, 2017 | Aug 20, 2019 (actual) |
| NCT03254485 | A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (HFpEF) | Phase 2 | Completed | Nov 7, 2017 | Aug 19, 2019 (actual) |
| NCT01906489 | 20-Week Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia | Phase 2 | Completed | Jul 23, 2013 | Sep 3, 2014 (actual) |
| NCT02865850 | Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Participants With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD) | Phase 3 | Completed | 2016-07 | Jan 31, 2020 (actual) |
| NCT01381094 | 42-Day Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia | Phase 2 | Completed | Jun 15, 2011 | Feb 16, 2012 (actual) |
| NCT01235936 | Safety and Efficacy Study for AKB-6548 in Participants With Chronic Kidney Disease and Anemia | Phase 2 | Completed | Oct 21, 2010 | Apr 13, 2011 (actual) |
| NCT02260193 | 16-Week Repeat Oral Dose Study of AKB-6548 for Anemia in Participants With End Stage Renal Disease (ESRD) Requiring Chronic Hemodialysis | Phase 2 | Completed | Sep 10, 2014 | Jul 22, 2015 (actual) |
| NCT02892149 | Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Dialysis-dependent Chronic Kidney Disease (DD-CKD) | Phase 3 | Completed | 2016-08 | Jan 16, 2020 (actual) |
| NCT04707573 | Study to Assess the Safety and Pharmacokinetics of AKB-6548 in Participants With Chronic Kidney Disease (CKD), Stages 3 and 4 | Phase 2 | Completed | Jul 8, 2010 | Sep 24, 2010 (actual) |
| NCT02648347 | Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease | Phase 3 | Completed | 2015-12 | Jun 4, 2020 (actual) |
| NCT02680574 | Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD) | Phase 3 | Completed | 2016-02 | Jun 18, 2020 (actual) |
| NCT03054350 | Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Dialysis-Dependent Chronic Kidney Disease (DD-CKD) | Phase 2 | Completed | 2016-12 | Oct 24, 2017 (actual) |
| NCT03054337 | Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Non-Dialysis Dependent Chronic Kidney Disease (NDD-CKD) | Phase 2 | Completed | 2016-10 | Jul 4, 2017 (actual) |
| NCT03140722 | Study to Evaluate Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) Who Are Hyporesponsive to Erythropoiesis Stimulating Agents | Phase 2 | Terminated | May 2, 2017 | Mar 21, 2018 (actual) |
| NCT04299633 | Study in Healthy Adult Subjects to Assess the Effect of Phosphate Binders on the Pharmacokinetics of a Single Dose of Vadadustat | Phase 1 | Completed | Jun 15, 2020 | Aug 2, 2020 (actual) |
| NCT03992066 | Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Vadadustat in Hemodialysis Subjects With Anemia Associated With Chronic Kidney Disease | Phase 1 | Completed | May 28, 2019 | May 5, 2020 (actual) |
| NCT03639155 | A Study in Evaluating Bioequivalence Between Test and Reference Formulations of Vadadustat Tablets in Healthy Adults | Phase 1 | Completed | Apr 12, 2018 | May 23, 2018 (actual) |
| NCT03657290 | A Study in Evaluating Bioequivalence of Test and Reference Vadadustat 450 MG and 150 MG Tablets and to Determine Food Effect on the 450 MG Tablet | Phase 1 | Completed | Aug 3, 2018 | Oct 16, 2018 (actual) |
| NCT03801733 | Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin | Phase 1 | Completed | Jun 17, 2018 | Nov 24, 2018 (actual) |
| NCT03801759 | Drug-Drug Interaction Study of Vadadustat With Digoxin, Adefovir and Furosemide | Phase 1 | Completed | Jul 20, 2018 | Sep 30, 2018 (actual) |
| NCT03801746 | Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin | Phase 1 | Completed | Jul 20, 2018 | Aug 15, 2018 (actual) |
| NCT03799848 | A Single Dose Study of Oral Vadadustat in Subjects With Normal and Impaired Hepatic Function | Phase 1 | Completed | Jun 12, 2018 | Oct 18, 2018 (actual) |
| NCT03789032 | Study to Evaluate the Effect of Rabeprazole on the Pharmacokinetics of Vadadustat | Phase 1 | Completed | Oct 3, 2018 | Nov 9, 2018 (actual) |
| NCT02502500 | Effect of AKB-6548 on the Pharmacokinetics of Celecoxib | Phase 1 | Completed | 2015-07 | 2015-07 (actual) |
| NCT02412449 | Relative Bioavailability of Two Formulations of AKB-6548 and the Food Effect of a New Tablet in Healthy Adult Subjects | Phase 1 | Completed | 2015-04 | 2015-04 (actual) |
| NCT02327546 | Effects of Ferrous Sulfate on the Pharmacokinetics of AKB-6548 | Phase 1 | Completed | 2014-12 | 2014-12 (actual) |
| NCT02062203 | Effect of AKB-6548 on Cardiac Repolarization Intervals in Healthy Volunteers | Phase 1 | Completed | 2014-01 | 2014-04 (actual) |
| NCT03242967 | Study to Evaluate Three Times Per Week (TIW) Oral Dosing of Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) | Phase 3 | Withdrawn | 2017-08 | Feb 12, 2018 (actual) |
